Top 5 Anime Like The Apothecary Diaries Season 2 (Kusuriya no Hitorigoto 2nd Season) [2025 List]

Kusuriya no Hitorigoto 2nd Season

The second season of Kusuriya no Hitorigoto.

Maomao and Jinshi face palace intrigue as a pregnant concubine's safety and a looming conspiracy collide.

The Apothecary Diaries Season 2 is currently airing and will have 24 Episodes. It is also Known as: 薬屋のひとりごと 第2期, The Pharmacist's Monologue, Drugstore Soliloquy

Genres: Drama , Mystery , China , Historical

Try our anime quiz: Anime Characters Guessing Quiz/Game

Top 5 Anime Like The Apothecary Diaries Season 2 (Kusuriya no Hitorigoto 2nd Season) [2025 List]

5. Vanitas no Carte Part 2

Vanitas no Carte Part 2

The second cour of Vanitas no Carte.

It’s 19th-century Paris, and young vampire Noé hunts for the Book of Vanitas. Attacked by a vampire driven insane, a human doctor called Vanitas tempts Noé with a mad crusade to “cure” the entire vampire race. While allying with him may be dangerous, news reaches Vanitas that the Beast of Gévaudan has returned, and Noé is being brought along to investigate this phantom from the past.

The Case Study of Vanitas Part 2 has finished airing and it has 12 Episodes. It is also Known as: ヴァニタスの手記 2クール, Vanitas no Shuki, Memoir of Vanitas

You might like: Top Anime Like The Case Study of Vanitas Part 2

4. Kusuriya no Hitorigoto

Kusuriya no Hitorigoto

Maomao lived a peaceful life with her apothecary father. Until one day, she’s sold as a lowly servant to the emperor’s palace. But she wasn’t meant for a compliant life among royalty. So when imperial heirs fall ill, she decides to step in and find a cure! This catches the eye of Jinshi, a handsome palace official who promotes her. Now, she’s making a name for herself solving medical mysteries!

The Apothecary Diaries has finished airing and it has 24 Episodes. It is also Known as: 薬屋のひとりごと, Drugstore Soliloquy

You might like: Top Anime Like The Apothecary Diaries

3. Vanitas no Carte

Vanitas no Carte

It’s 19th-century Paris, and young vampire Noé hunts for the Book of Vanitas. Attacked by a vampire driven insane, a human intercedes, rescues Noé, and heals the sick creature. Commanding the book and calling himself Vanitas, this doctor tempts Noé with a mad crusade to “cure” the entire vampire race. Allying with one who wields arcane power so easily may be dangerous, but does he have a choice?

The Case Study of Vanitas has finished airing and it has 12 Episodes. It is also Known as: ヴァニタスの手記, Vanitas no Shuki, Memoir of Vanitas

You might like: Top Anime Like The Case Study of Vanitas

2. Mushishi

Mushishi

"Mushi": the most basic forms of life in the world. They exist without any goals or purposes aside from simply "being." They are beyond the shackles of the words "good" and "evil." Mushi can exist in countless forms and are capable of mimicking things from the natural world such as plants, diseases, and even phenomena like rainbows.
This is, however, just a vague definition of these entities that inhabit the vibrant world of Mushishi, as to even call them a form of life would be an oversimplification. Detailed information on Mushi is scarce because the majority of humans are unaware of their existence.
So what are Mushi and why do they exist? This is the question that a "Mushi-shi," Ginko, ponders constantly. Mushi-shi are those who research Mushi in hopes of understanding their place in the world's hierarchy of life.
Ginko chases rumors of occurrences that could be tied to Mushi, all for the sake of finding an answer.
It could, after all, lead to the meaning of life itself.

Mushi-Shi has finished airing and it has 26 Episodes. It is also Known as: 蟲師, Mushishi

You might like: Top Anime Like Mushi-Shi

1. Baccano!

Baccano!

During the early 1930s in Chicago, the transcontinental train, Flying Pussyfoot, is starting its legendary journey that will leave a trail of blood all over the country. At the same time in New York, the ambitious scientist Szilard and his unwilling aide Ennis are looking for missing bottles of the immortality elixir. In addition, a war between the mafia groups is getting worse. On board the Advena Avis, in 1711, alchemists are about to learn the price of immortality.
Based on the award-winning light novels of the same name, Baccano! follows several events that initially seem unrelated, both in time and place, but are part of a much bigger story—one of alchemy, survival and immortality. Merging these events together are the kindhearted would-be thieves, Isaac and Miria, connecting various people, all of them with their own hidden ambitions and agendas, and creating lifelong bonds and consequences for everyone involved.

Baccano! has finished airing and it has 13 Episodes. It is also Known as: バッカーノ!, Baccano!

You might like: Top Anime Like Baccano!
Amagami SS

Top Anime Like Amagami SS

  • Anime
  • Recommendations
Tengen Toppa Gurren Lagann Movie 2: Lagann-hen

Top Anime Like Gurren Lagann The Movie: The Lights in the Sky are Stars

  • Anime
  • Recommendations
Blood-C

Top Anime Like BLOOD-C

  • Anime
  • Recommendations
Zero no Tsukaima F

Top Anime Like The Familiar of Zero F

  • Anime
  • Recommendations
Fullmetal Alchemist: The Movie - Conqueror of Shamballa

Top Anime Like Fullmetal Alchemist: The Movie - Conqueror of Shamballa

  • Anime
  • Recommendations
Jigoku Shoujo

Top Anime Like Hell Girl

  • Anime
  • Recommendations
Hajimete no Gal

Top Anime Like My First Girlfriend is a Gal

  • Anime
  • Recommendations
Little Busters!

Top Anime Like Little Busters!

  • Anime
  • Recommendations